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BindCraft proved that back-propagating through AlphaFold works. Four follow-ups — BindEnergyCraft, FoldCraft, Germinal and mBER — each repair a different gap, and together they argue that the field's real contest is about where to put the constraints.
AlphaFold3-class predictors hallucinate plausible structures even from all-X sequences. Protein Hunter turns that failure mode into a zero-shot design loop: hallucinate a structure, inverse-fold a sequence, re-predict, repeat.
BindCraft and its relatives turned AlphaFold2 into a scoring function and back-propagated through it to hallucinate binders. A survey of how that idea works, what it buys us, and where it still breaks.
