3 post(s). All tags
RFdiffusion went from residue-level backbone generation to all-atom interaction design in about two years. Reading the RFD1, RFD2 and RFD3 papers as one arc, and what each generation actually changed.
Notes on the Structure review "Code to complex: AI-driven de novo binder design" — forty years from rational design to generative design, the four current design philosophies, and where the bench-to-bedside stories already are.
BindCraft and its relatives turned AlphaFold2 into a scoring function and back-propagated through it to hallucinate binders. A survey of how that idea works, what it buys us, and where it still breaks.
